Compliance & Compatibility

Our DF30 metering valve has been the proven industry standard for pressurized metered-dose inhalers (pMDIs) for more than 25 years. They power many inhalation drug products marketed worldwide for asthma and COPD. With constant improvements and optimizations, Aptar Pharma’s DF30 pMDI metering valves continue to set new standards through materials, design, and support.
Aptar Pharma’s in-house pMDI valves and actuators work with a wide range of formulations and our integrated services offering can help accelerate and derisk your next OINDP product development.

Robust Design, optimization and development for asthma inhalers

Aptar Pharma’s design and development team incorporates the DF30 metering valves that result in high-performance and reliability of asthma inhalers. We offer high-quality lab tested elastomeric options that provide both product integrity and compatibility over the life of the product. The robust metering valve design delivers accurate and consistent inhaled drug delivery to patients.

The standard metering valve for asthma inhalers, DF30

Aptar Pharma’s DF30 metering valve represents proven quality in performance in pressurized metered-dose inhalers (pMDIs) drug delivery. The DF30 metering valve technology is incorporated into high-volume prescription drug products marketed worldwide for asthma and COPD. It is approved for use in major markets around the world including Asia, Europe, Latin America, and the U.S.A. With three high-quality metering valve manufacturing facilities located strategically in Europe and Asia, Aptar Pharma can provide security of supply to customers anywhere. Manufacturing sites are quality focused and maintain compliance with the increasingly stringent regulatory requirements of major regulatory bodies including the EMA, and U.S. FDA.

The DF30 metering valve line has undergone continuous improvements and  optimizations over decades to maintain its position as one of the most trusted and relied upon metering valve in the pMDI industry. We’ve achieved this through our dedication to R&D and commitment to sustainability. Compatible with traditional HFA propellants, the DF30 line of metering valves has been optimized to work seamlessly with other lower Global Warming Potential (GWP) propellant options, like P152a or 1234ze, thus reducing the environmental impact of our valves.

Aptar Pharma has strategic sustainability goals to meet across its operations and through its new product designs, which use Eco-Design tools and Quality by Design (QbD) principles to achieve them. The DF30 metering valve technology is the industry standard for pMDI applications.

Integrated Support Services for OINDPs

All our metering valves for OINDPs are supported with comprehensive analytical, formulation and regulatory services and support to move our customer’s products to market. These complete services and support can help to derisk and accelerate the development process for new or generic pMDI products. Our regulatory support teams know the way to approval of pressurized metered dose inhaler products containing our DF30 metering valves. We can provide extractable and toxicology dossiers to support customer regulatory filings. Aptar Pharma are also formulation experts and can develop inhalable formulations that are optimized for use in our devices and metering valves. With in-house pilot filling equipment and off the shelf formulation development services we can streamline this complex development activity. Our specialized analytical laboratories can complete e extractable and leachable studies, perform bioburden, silicon oil assays as well as prepare full extractable and toxicology packages to support customer regulatory filings. We also analyze physical properties such as aerodynamic sizing and spray characteristics, as well as mechanical, stress and content uniformity and moisture content testing. We are specialists in developing pMDI products, so you don’t have to be.